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Metformin reduces thyroid cancer tumor growth
Edwin- posted on
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Metformin reduces thyroid most cancers tumor progress within the metastatic area of interest of bone by inhibiting osteoblastic RANKL productions
Background Metformin has antitumoral actions in human cancers together with the thyroid, whereas its results on metastatic lesions is unclear. Sufferers with bone metastasis (BM) from thyroid cancers have poor survival. As a result of metformin inhibits the activation of osteoclasts, which has important roles in BM, the goal of this examine was to analyze the therapeutic results of metformin on thyroid most cancers BM and osteoclast activation within the bone microenvironment.
Strategies
The anaplastic thyroid most cancers (ATC) cell traces FRO and SW1736 have been used to check the antitumoral impact of metformin in vitro and in vivo. A murine mannequin of BM was established by intra-tibial injection of most cancers cells. To imitate the BM microenvironment, osteoblasts have been handled with conditioned media from the FRO (FRO-CM) and SW1736 (SW1736-CM) cells.
Thyroid most cancers sufferers with or with out BM have been recruited, and serum RANKL ranges have been measured. Outcomes Metformin therapy considerably diminished the viabilities of the FRO and SW1736 cells in vitro and the tumor progress of SW1736 in vivo. Within the murine mannequin of BM, metformin delayed tumor progress within the bone and decreased the numbers of TRAP-positive osteoclasts on the bone floor with diminished RANKL within the bone marrow.
Moreover, FRO- or SW1736-CM considerably elevated the osteoblastic RANKL productions and activated osteoclast differentiation in entire marrow cultures, which have been blocked by metformin therapy. Amongst 67 thyroid most cancers sufferers, the serum RANKL ranges have been considerably elevated in BM sufferers in comparison with sufferers with lung solely metastasis or no distant metastasis.
Moreover, IL-6 superfamily within the FRO- or SW1736-CM stimulated STAT3 phosphorylation, which was inhibited by gp130 blocking. Metformin therapy decreased the FRO- or SW1736-CM-induced STAT3 phosphorylation by AMPK phosphorylation.
Metformin additionally inhibited the FRO- or SW1736-CM-induced osteoclastic differentiation of bone marrow-derived monocyte macrophage (BMM) by RANK/c-Fos/NFATC1 signaling.
Conclusions
Within the microenvironment of BM, metformin successfully diminished ATC tumor progress by inhibiting most cancers cell viability, blocking most cancers cell induced osteoblastic RANKL manufacturing, which additional activated osteoclastogenesis, and immediately diminished osteoclast differentiation. These multifactorial actions of metformin suggests it has potential therapeutic results in thyroid most cancers BM.
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CD45RA antibody |
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Description: Mouse monoclonal CD45RA antibody |
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CD45RA antibody |
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Description: Mouse monoclonal CD45RA antibody |
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anti-CD8 T cytotoxic/supressor cells |
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| 505-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD8 T cytotoxic/supressor cells |
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anti-CD8 T cytotoxic/supressor cells |
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| 505-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD8 T cytotoxic/supressor cells |
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anti-CD8 T cytotoxic/supressor cells |
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| 505-A-100ugvial | Virogen | 100 ug/vial | EUR 150 |
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Description: anti-CD8 T cytotoxic/supressor cells |
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CD45RA(111-1C5) Antibody |
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| BNC941038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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Description: Primary antibody against CD45RA(158-4D3), APC conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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Description: Primary antibody against CD45RA(158-4D3), CF680R conjugate, Concentration: 0.1mg/mL |
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Description: Primary antibody against CD45RA(158-4D3), CF680R conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC800028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF680 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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Description: Primary antibody against CD45RA(158-4D3), CF680 conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC811038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC811038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC940028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF594 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC940028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF594 conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC701038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC701038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC881038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC881038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC880028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF488A conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC880028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF488A conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC051038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC051038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC041038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC041038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC430028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF543 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC430028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF543 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC400028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF640R conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC400028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF640R conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC401038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNC401038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC050028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF405M conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC050028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF405M conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCB0028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), Biotin conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCB1038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCB1038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCAP1038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCAP1038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCA1038-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against CD45RA(111-1C5), APC conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCAP0028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCAP0028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCB0028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), Biotin conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCR0028-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against CD45RA(158-4D3), RPE conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCR1038-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against CD45RA(111-1C5), RPE conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNUB0028-100 | Biotium | 100uL | EUR 250.8 |
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Description: Primary antibody against CD45RA(158-4D3), Concentration: 0.2mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNUB0028-500 | Biotium | 500uL | EUR 549.6 |
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Description: Primary antibody against CD45RA(158-4D3), Concentration: 0.2mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCP0028-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against CD45RA(158-4D3), PerCP conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCP1038-250 | Biotium | 250uL | EUR 459.6 |
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Description: Primary antibody against CD45RA(111-1C5), PerCP conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCH0028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNCH0028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNUM0028-50 | Biotium | 50uL | EUR 474 |
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Description: Primary antibody against CD45RA(158-4D3), 1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNUM1038-50 | Biotium | 50uL | EUR 474 |
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Description: Primary antibody against CD45RA(111-1C5), 1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCH1038-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNCH1038-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNUB1038-100 | Biotium | 100uL | EUR 250.8 |
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Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL |
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CD45RA(111-1C5) Antibody |
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| BNUB1038-500 | Biotium | 500uL | EUR 549.6 |
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Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC040028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF405S conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC040028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF405S conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC550028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF555 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC550028-500 | Biotium | 500uL | EUR 652.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF555 conjugate, Concentration: 0.1mg/mL |
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CD45RA(158-4D3) Antibody |
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| BNC610028-100 | Biotium | 100uL | EUR 238.8 |
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Description: Primary antibody against CD45RA(158-4D3), CF660R conjugate, Concentration: 0.1mg/mL |
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DNA methylation standing of imprinted H19 and KvDMR1 genes in human placentas after conception utilizing assisted reproductive expertise
Background: Assisted reproductive applied sciences (ARTs), corresponding to in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), are thought to destabilize genomic imprints. Earlier research inspecting the affiliation between ART and aberrant DNA methylation have been inconclusive.
Technique: The DNA methylation standing of H19 and KvDMR1 was in contrast between newborns conceived by way of ART and people conceived naturally to guage the protection of ART. Placental tissues from 6 full-term, naturally conceived pregnancies (no gestational comorbidities) and 6 full-term ART pregnancies (no gestational complication) have been collected.
Genomic DNA (gDNA) and RNA have been extracted from each teams. Actual-time PCR was used to research the mRNA expression ranges of H19 and KvDMR1 within the placenta for each teams. A complete-genome DNA methylation microarray was used to look at three placentas from full-term, naturally conceived pregnancies and three placentas from full-term IVF pregnancies.
End result: The expression degree of H19 within the IVF group was considerably increased than that within the pure being pregnant group, whereas the expression degree of KvDMR1 was considerably decrease within the ART group than within the pure being pregnant group. Additionally, human ART manipulation resulted in placental gDNA methylation modifications.
Conclusion: Irregular methylation patterns have been detected in phenotypically regular phenotype conceived by ART, which can happen because of imprinting errors in sperm/oocyte cells or unwanted side effects of in vitro embryo tradition procedures. Additional investigation is important to decide whether or not imprinted gene expression and DNA methylation could be regulated by way of different mechanisms.
Key phrases: Assisted reproductive expertise (ART); placenta; methylation; H19; KvDMR1.
Human Umbilical Cord PrimaCell4: Normal Umbilical Vein Endothelial Cells Growth Medium |
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| 9-46109 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord Mesenchymal Stem Cells With GFP |
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| HUXUC-01101 | Cyagen | 1*10^6/vial | EUR 1599 |
Rat Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells |
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| 2-82587 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord PrimaCell1: Normal Umbilical Artery Endothelial Cells Growth Medium |
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| 9-46106 | CHI Scientific | 5 x 100 ml | Ask for price |
Mouse Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells |
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| 2-82091 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord PrimaCell5: Normal Umbilical Vein Smooth Muscle Cells Growth Medium |
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| 9-46110 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord PrimaCell2: Normal Umbilical Artery Smooth Muscle Cells Growth Medium |
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| 9-46107 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 4: Normal Umbilical Vein Endothelial Cells |
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| 9-80109 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 1: Normal Umbilical Artery Endothelial Cells |
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| 9-80106 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 5: Normal Umbilical Vein Smooth Muscle Cells |
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| 9-80110 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 2: Normal Umbilical Artery Smooth Muscle Cells |
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| 9-80107 | CHI Scientific | 1 x 100 ml | Ask for price |
Complete Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90011 | Cyagen | 500mL | EUR 319 |
Rat Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Medium |
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| 9-25087 | CHI Scientific | 5 x 100 ml | Ask for price |
Mouse Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Medium |
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| 9-32091 | CHI Scientific | 5 x 100 ml | Ask for price |
Rat Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
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| 9-80294 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
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| 9-80205 | CHI Scientific | 1 x 100 ml | Ask for price |
Serum Free Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90061 | Cyagen | 500mL | EUR 399 |
Fetal Umbilical Cord Lysate |
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| XBL-10430 | ProSci | 0.1 mg | EUR 500.1 |
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Description: Fetal human umbilical cord tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human umbilical cord tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the umbilical cord tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The umbilical cord tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
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Human Umbilical Cord PrimaCell1: Normal Umbilical Artery Endothelial Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47106 | CHI Scientific | 1 Set | Ask for price |
Human Umbilical Cord PrimaCell4: Normal Umbilical Vein Endothelial Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47109 | CHI Scientific | 1 Set | Ask for price |
Human Umbilical Cord PrimaCell5: Normal Umbilical Vein Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47110 | CHI Scientific | 1 Set | Ask for price |
Osteogenic Differentiation Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90021 | Cyagen | 200mL | EUR 250 |
Adipogenic Differentiation Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90031 | Cyagen | 200+100mL | EUR 359 |
Chondrogenic Differentiation Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90041 | Cyagen | 100mL | EUR 409 |
Human Umbilical Cord PrimaCell2: Normal Umbilical Artery Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47107 | CHI Scientific | 1 Set | Ask for price |
Rat Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-26087 | CHI Scientific | 1 Set | Ask for price |
Mouse Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-33091 | CHI Scientific | 1 Set | Ask for price |
Human Umbilical Cord OptiTDS1: Tissue Dissociation System |
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| 4-28106 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord OptiTDS2: Tissue Dissociation System |
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| 4-28107 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord OptiTDS4: Tissue Dissociation System |
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| 4-28109 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord OptiTDS5: Tissue Dissociation System |
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| 4-28110 | CHI Scientific | 1 Kit | Ask for price |
Human ; Umbilical Vein Endothelial Cells |
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| 02-701 | Sceti | 100ng | EUR 481.2 |
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Description: The Human ; Umbilical Vein Endothelial Cells is available in Europe and for worldwide shipping via Gentaur. |
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Human Umbilical Vein Endothelial Cells |
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| HEC01 | Neuromics | 500,000+ Cells frozen | EUR 528 |
Human Umbilical Vein Endothelial Cells |
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| HUVEC-20001 | Cyagen | 1*10^6/vial | EUR 1100 |
Rat Umbilical Cord OptiTDS: Tissue Dissociation System |
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| 4-28294 | CHI Scientific | 1 Kit | Ask for price |
Mouse Umbilical Cord OptiTDS: Tissue Dissociation System |
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| 4-28205 | CHI Scientific | 1 Kit | Ask for price |
GFP Expressing Human Umbilical Vein Endothelial Cells |
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| GF01 | Neuromics | 500,000+ Cells frozen | EUR 1248 |
Human Umbilical Cord FibrOut1: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15095 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord FibrOut2: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15096 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord FibrOut4: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15098 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord FibrOut5: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15099 | CHI Scientific | 1 Kit | Ask for price |
Immortalized Human Umbilical Vein Endothelial Cells - SV40 |
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| T0014 | ABM | 1x106 cells / 1.0 ml | Ask for price |
Complete Medium For Human Umbilical Vein Endothelial Cells |
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| HUVEC-90011 | Cyagen | 500mL | EUR 319 |
CORNING®HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS, HUVEC-2 CELLS (>5X105 CELLS), 1 CRYOVIAL/PACK |
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| 354151 | CORNING | 1/pk | EUR 465.6 |
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Description: Permeable Support - DL; Coated Transwells - DL |
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human umbilical vein endothelial cells, Peptide Aptamer, unlabeled |
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| AP-316-U | Alpha Diagnostics | 5 mg | Ask for price |
Rat Umbilical Cord FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15264 | CHI Scientific | 1 Kit | Ask for price |
human umbilical vein endothelial cells, Peptide Aptamer, Biotinylated |
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| AP-316-B | Alpha Diagnostics | 1 mg | Ask for price |
Mouse Umbilical Cord FibrOut: Fibroblast Inhibitory System (for 500 ml medium) |
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| 7-15184 | CHI Scientific | 1 Kit | Ask for price |
human umbilical vein endothelial cells, Peptide Aptamer, FITC labelled |
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| AP-316-F | Alpha Diagnostics | 1 mg | Ask for price |
VEGF-stimulated human umbilical vein endothelial cells, Peptide Aptamer, unlabeled |
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| AP-339-U | Alpha Diagnostics | 5 mg | Ask for price |
VEGF-stimulated human umbilical vein endothelial cells, Peptide Aptamer, Biotinylated |
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| AP-339-B | Alpha Diagnostics | 1 mg | Ask for price |
VEGF-stimulated human umbilical vein endothelial cells, Peptide Aptamer, FITC labelled |
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| AP-339-F | Alpha Diagnostics | 1 mg | Ask for price |
Human Cord Blood CD34+ Cells Derived Endothelial Cells |
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| HEC23 | Neuromics | 500,000+ Cells | EUR 1296 |
Human Cord Blood CD34+ Cells, Cryopreserved, single donor |
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| CBCD34-C0.5M | 101Bio | - | Ask for price |
Human Cord Blood CD34+ Cells, Cryopreserved, mixed donor |
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| CBCD34mix-C0.5M | 101Bio | - | Ask for price |
Human Cord Blood CD34+ Cells, Cryopreserved, mixed donor |
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| CBCD34mix-C1M | 101Bio | - | Ask for price |
Human Cord Blood CD34+ Cells, Cryopreserved, mixed donor |
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| CBCD34mix-C5M | 101Bio | - | Ask for price |
Human Cord Blood CD34+ Cells, Cryopreserved, single donor |
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| CBCD34-C1M | 101Bio | - | Ask for price |
VEGF-stimulated Human Umbilical Vein Endothelial Cell, Peptide Aptamer, unlabeled |
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| AP-338-U | Alpha Diagnostics | 5 mg | Ask for price |
VEGF-stimulated Human Umbilical Vein Endothelial Cell, Peptide Aptamer, Biotinylated |
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| AP-338-B | Alpha Diagnostics | 1 mg | Ask for price |
VEGF-stimulated Human Umbilical Vein Endothelial Cell, Peptide Aptamer, FITC labelled |
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| AP-338-F | Alpha Diagnostics | 1 mg | Ask for price |
Human  Cord  Blood  CD34+  Cells (Mixed  Donors) |
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| CBCD34M-05 | 101Bio | - | Ask for price |
Human  Cord  Blood  CD34+  Cells (Mixed  Donors) |
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| CBCD34M-1 | 101Bio | - | Ask for price |
Human  Cord  Blood  CD34+  Cells (Mixed  Donors) |
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| CBCD34M-5 | 101Bio | - | Ask for price |
Human  Cord  Blood  CD34+  Cells (Single  Donor) |
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| CBCD34S-05 | 101Bio | - | Ask for price |
Human  Cord  Blood  CD34+  Cells (Single  Donor) |
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| CBCD34S-1 | 101Bio | - | Ask for price |
Human Normal Peripheral Blood CD4+/CD25+ Regulatory T Cells (T reg), Fresh |
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| PBCD4-25-F2M | 101Bio | - | Ask for price |
Human Normal Peripheral Blood CD4+/CD25+ Regulatory T Cells (T reg), Cryopreserved |
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| PBCD4-25-C2M | 101Bio | - | Ask for price |
Human Peripheral Blood CD3+Â T Cells, Fresh |
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| PBCD3-F20M | 101Bio | - | Ask for price |
Human Peripheral Blood CD3+Â T Cells, Cryopreserved |
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| PBCD3-C10M | 101Bio | - | Ask for price |
Human Peripheral Blood CD3+Â T Cells, Cryopreserved |
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| PBCD3-C20M | 101Bio | - | Ask for price |
Cancer Antigen AFP Antigen (Human Cord Blood) |
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| VAng-Wyb8624-inquire | Creative Biolabs | inquire | Ask for price |
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Description: Alpha Fetoprotein (66 kDa), Cancer antigen from Human Cord Blood, 1.73 mg/mL. |
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Unprocessed Human Cord Blood from IRB-approved donors, Fresh |
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| FC-001-F10 | 101Bio | - | Ask for price |
Unprocessed Human Cord Blood from IRB-approved donors, Fresh |
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| FC-001-F100 | 101Bio | - | Ask for price |
Unprocessed Human Cord Blood from IRB-approved donors, Fresh |
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| FC-001-F50 | 101Bio | - | Ask for price |
Unprocessed Human Cord Blood from IRB-approved donors, Fresh |
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| FC-001-F80 | 101Bio | - | Ask for price |
Dog Red Blood Cells |
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| 88R-D004 | Fitzgerald | 10 ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Dog Red Blood Cells |
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Pig Red Blood Cells |
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| 88R-P002 | Fitzgerald | 20 ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Pig Red Blood Cells |
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Rat Red Blood Cells |
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| 88R-R002 | Fitzgerald | 5 x 2.0ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Rat Red Blood Cells |
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Rat Red Blood Cells |
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| 88R-R005 | Fitzgerald | 25 ml | EUR 392.4 |
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Description: Washed and freshly prepared 10% suspension of Rat Red Blood Cells |
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Goat Red Blood Cells |
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| 88R-G003 | Fitzgerald | 20 ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Goat Red Blood Cells |
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Sheep Red Blood Cells |
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| 20R-RS001 | Fitzgerald | 10 ml | EUR 625.2 |
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Description: Human IgG Senstitized Gluteraldehyde Stabilized Sheep Red Bllood Cells |
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Horse Red Blood Cells |
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| 88R-H002 | Fitzgerald | 20 ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Horse Red Blood Cells |
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Mouse Red Blood Cells |
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| 88R-M001 | Fitzgerald | 10 ml | EUR 354 |
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Description: Washed and freshly prepared 10% suspension of Mouse Red Blood Cells |
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Mouse Red Blood Cells |
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| 88R-M004 | Fitzgerald | 5 x 2 ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Mouse Red Blood Cells |
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Sheep Red Blood Cells |
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| 88R-S001 | Fitzgerald | 100 ml | EUR 614.4 |
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Description: Washed and freshly prepared 10% suspension of Sheep Red Blood Cells |
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Sheep Red Blood Cells |
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| 88R-S003 | Fitzgerald | 20 ml | EUR 327.6 |
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Description: Glutaraldehyde-stabilized freshly prepared Sheep Red Blood Cells |
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Sheep Red Blood Cells |
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| 88R-S004 | Fitzgerald | 10 ml | EUR 625.2 |
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Description: Glutaraldehyde-stabilized freshly prepared albumin sensitised Sheep Red Blood Cells |
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