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Metformin reduces thyroid cancer tumor growth
Edwin- posted on
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Metformin reduces thyroid most cancers tumor progress within the metastatic area of interest of bone by inhibiting osteoblastic RANKL productions
Background Metformin has antitumoral actions in human cancers together with the thyroid, whereas its results on metastatic lesions is unclear. Sufferers with bone metastasis (BM) from thyroid cancers have poor survival. As a result of metformin inhibits the activation of osteoclasts, which has important roles in BM, the goal of this examine was to analyze the therapeutic results of metformin on thyroid most cancers BM and osteoclast activation within the bone microenvironment.
Strategies
The anaplastic thyroid most cancers (ATC) cell traces FRO and SW1736 have been used to check the antitumoral impact of metformin in vitro and in vivo. A murine mannequin of BM was established by intra-tibial injection of most cancers cells. To imitate the BM microenvironment, osteoblasts have been handled with conditioned media from the FRO (FRO-CM) and SW1736 (SW1736-CM) cells.
Thyroid most cancers sufferers with or with out BM have been recruited, and serum RANKL ranges have been measured. Outcomes Metformin therapy considerably diminished the viabilities of the FRO and SW1736 cells in vitro and the tumor progress of SW1736 in vivo. Within the murine mannequin of BM, metformin delayed tumor progress within the bone and decreased the numbers of TRAP-positive osteoclasts on the bone floor with diminished RANKL within the bone marrow.
Moreover, FRO- or SW1736-CM considerably elevated the osteoblastic RANKL productions and activated osteoclast differentiation in entire marrow cultures, which have been blocked by metformin therapy. Amongst 67 thyroid most cancers sufferers, the serum RANKL ranges have been considerably elevated in BM sufferers in comparison with sufferers with lung solely metastasis or no distant metastasis.
Moreover, IL-6 superfamily within the FRO- or SW1736-CM stimulated STAT3 phosphorylation, which was inhibited by gp130 blocking. Metformin therapy decreased the FRO- or SW1736-CM-induced STAT3 phosphorylation by AMPK phosphorylation.
Metformin additionally inhibited the FRO- or SW1736-CM-induced osteoclastic differentiation of bone marrow-derived monocyte macrophage (BMM) by RANK/c-Fos/NFATC1 signaling.
Conclusions
Within the microenvironment of BM, metformin successfully diminished ATC tumor progress by inhibiting most cancers cell viability, blocking most cancers cell induced osteoblastic RANKL manufacturing, which additional activated osteoclastogenesis, and immediately diminished osteoclast differentiation. These multifactorial actions of metformin suggests it has potential therapeutic results in thyroid most cancers BM.
Human Peripheral Blood CD8+ Naive T Killer Cells |
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| ABC-TC3989 | AcceGen | 1 vial | Ask for price |
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Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. |
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Human Cord Blood Naive T Helper Cells, CD4+ |
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| ABC-TC3970 | AcceGen | 1 vial | Ask for price |
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Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. A peripheral blood mononuclear cell is defined as any blood cell with a round nucleus. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of CD4+ and CD8+ T cells, B cells and Natural Killer cells, CD14+ Monocytes, and Basophils/Neutrophils/Eosinophils/Dendritic cells. These cells are often extracted from whole blood or from leukopacks using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma.Samples from each donor are tested via PCR to confirm non-reactivity. |
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Human Peripheral Blood CD4+ Naive T Helper Cells |
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| ABC-TC3988 | AcceGen | 1 vial | Ask for price |
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Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. |
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Human PB CD8+/CD45RA+ Naïve Cytotoxic T Cells |
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| ABC-TC4006 | AcceGen | 1 vial | Ask for price |
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Description: First, NPB-CD8+ T Cells (CTL) are negatively isolated from Mononuclear Cells using immunomagnetic CD8+ T cell isolation kit. Next, CD45RO MicroBeads are used to deplete the CD45RO+ cell population, leaving a purified CD8+/CD45RA+ Naïve T Cell population. |
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Human CD4+/CD45RA+/CD25-Naïve T Cells |
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| ABC-TC4003 | AcceGen | 1 vial | Ask for price |
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Description: First, NPB-CD4+ T Cells are negatively isolated using immunomagnetic CD4+ isolation kit from mononuclear cells. Next, CD45RO MicroBeads are used to deplete the CD45RO+ cell population, leaving an untouched, purified CD4+/CD45RA+ Naïve T Cell population. |
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Human Cord Blood CD4+/CD45RA+ Naïve T Cells |
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| ABC-TC3377 | AcceGen | 1 vial | Ask for price |
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Description: First, Cord Blood-CD4+ T Cells are negatively isolated using an indirect immunomagnetic CD4+ labeling system from mononuclear cells. Next, CD45RO MicroBeads are used to deplete the CD45RO+ population, leaving a purified CD4+/CD45RA+ Naïve T Cell population. |
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Rat CD45Ra Antibody (B Cells Only) |
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| GWB-6A11BA | GenWay Biotech | 0.25 mg | Ask for price |
Rat CD45Ra Antibody (B Cells Only) |
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| GWB-F09251 | GenWay Biotech | 1 mg | Ask for price |
Rat CD45Ra Antibody (B Cells Only) |
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| GWB-D60850 | GenWay Biotech | 0.1 mg | Ask for price |
MOUSE ANTI RAT CD45RA (B CELLS ONLY) |
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| MBS212979-1mg | MyBiosource | 1mg | EUR 805 |
MOUSE ANTI RAT CD45RA (B CELLS ONLY) |
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| MBS212979-5x1mg | MyBiosource | 5x1mg | EUR 3440 |
MOUSE ANTI RAT CD45RA (B CELLS ONLY) |
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| MBS212980-01mg | MyBiosource | 0.1mg | EUR 365 |
MOUSE ANTI RAT CD45RA (B CELLS ONLY) |
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| MBS212980-5x01mg | MyBiosource | 5x0.1mg | EUR 1465 |
MOUSE ANTI RAT CD45RA (B CELLS ONLY) |
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| MBS212981-025mg | MyBiosource | 0.25mg | EUR 515 |
MOUSE ANTI RAT CD45RA (B CELLS ONLY) |
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| MBS212981-5x025mg | MyBiosource | 5x0.25mg | EUR 2145 |
CD45RA/CD45RO/CD3/CD8 |
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| 45RAF245ROPE3PP18A3-50T | ImmunoStep | 50 test | EUR 730.8 |
CD45RA/CD62L/CD3/CD8 |
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| 45RAF262LPE3PP18A3-50T | ImmunoStep | 50 test | EUR 730.8 |
CD8 FITC - CD45RA PE |
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| MBS396217-100Tests | MyBiosource | 100Tests | EUR 485 |
CD8 FITC - CD45RA PE |
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| MBS396217-5x100Tests | MyBiosource | 5x100Tests | EUR 2045 |
CD8+ T Cells-Lupus |
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| ABC-SC0155T | AcceGen | 1 vial | Ask for price |
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Description: SLE CD8+ T Cells are available from Gentaur. All are listed on the certificate of analysis provided with each lot. |
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Human PB CD8+ T Cells |
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| ABC-TC4005 | AcceGen | 1 vial | Ask for price |
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Description: NPB-CD8+ Cytotoxic T cells are negatively isolated from Mononuclear Cells using an indirect immunomagnetic CD8+ T cell labeling system. |
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CD45RA (FITC) CD8 (RPE) Antibody |
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| GWB-Q01598 | GenWay Biotech | 50 TESTS | Ask for price |
Rat Splenocytes CD8+ T cells |
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| ABC-TC4226 | AcceGen | 1 vial | Ask for price |
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Description: Rat spleen is mechanically dissociated into a single cell suspension. The splenocytes are enriched by density separation. CD4+ T cells, CD8+ T Cells, and CD45R+ B Cells and then isolated using specific immunomagnetic methods. |
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CD45RA, B cell Antibody, Ready-T-Use |
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| MAB870P | Innovex | 7ml | EUR 435 |
CD45RA (FITC) / CD8 (PE) Combination Antibody |
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| abx410005-100tests | Abbexa | 100 tests | EUR 512.5 |
CD45RA (FITC) / CD8 (RPE) Combination Antibody |
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| abx410005-50tests | Abbexa | 50 tests | EUR 744 |
Human CD8+ Cytotoxic Killer T Cells |
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| T4121 | ABM | 5x10^5 cells / 1.0 ml | EUR 975 |
Immortalized Mouse CD4+ CD8+ T Cells (MOHITO) |
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| T0131 | ABM | 1x106 cells / 1.0 ml | EUR 3950 |
CD8+ T cells, Negatively Selected (Human) |
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| 79753 | BPS Bioscience | 10 million cells | EUR 495 |
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Description: Cryopreserved vial (10 x 10^6 cells) of CD8+ T cells that were negatively selected from freshly isolated primary human peripheral blood mononuclear cells (PBMCs). The PBMCs came from a healthy donor, and were isolated from whole blood or leukapheresis samples using a Ficoll gradient. Magnetic antibodies to monocytes, granulocytes, CD4+ T cells, gamma/delta T cells and other immune subsets present in PBMCs were then used to purify untouched CD8+ T cells via immunomagnetic separation. Before and after CD8+ T cell isolation, the cells were stained to evaluate purity and viability by flow cytometry. Cells were cryopreserved in CryoStor CS10 cryopreservation medium (Stemcell, #07930) at a controlled rate._x000D_Source Normal human PBMC from Leukapheresis Sample |
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Human Cord Blood CD8+ Cytotoxic T Cells |
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| ABC-TC3379 | AcceGen | 1 vial | Ask for price |
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Description: Cord Blood-CD8+ Cytotoxic T cells are negatively isolated from mononuclear cells, using an indirect immunomagnetic CD8 labeling system to deplete the non-CD8+ cells. |
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Human Cord Blood CD8+ Cytotoxic T Cells |
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| CBCD8-C5M | 101Bio | 5 million | EUR 958.8 |
Human Cord Blood CD8+ Cytotoxic T Cells |
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| CBCD8-F5M | 101Bio | 5 million | EUR 1078.8 |
Human Peripheral Blood CD8+ T Killer Cells |
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| ABC-TC3991 | AcceGen | 1 vial | Ask for price |
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Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. |
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CD45RA / CD45RO / CD3 / CD8 Antibody (FITC, PE, PerCP, APC) |
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| abx200641-50tests | Abbexa | 50 tests | EUR 828 |
CD45RA / CD62L / CD3 / CD8 Antibody (FITC, PE, PerCP, APC) |
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| abx200643-50tests | Abbexa | 50 tests | EUR 828 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx413329-01mg | Abbexa | 0.1 mg | EUR 543.6 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx413626-2ml | Abbexa | 2 ml | EUR 727.2 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx414688-1mg | Abbexa | 1 mg | EUR 994.8 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx414689-01mg | Abbexa | 0.1 mg | EUR 526.8 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx414691-025mg | Abbexa | 0.25 mg | EUR 678 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx415596-02mg | Abbexa | 0.2 mg | EUR 678 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx415611-20ug | Abbexa | 20 ug | EUR 326.4 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx139821-100g | Abbexa | 100 µg | EUR 275 |
CD45RA Antigen (CD45RA/PTPRC) Antibody |
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| abx228505-100g | Abbexa | 100 µg | EUR 87.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody |
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| abx413329-200l | Abbexa | 200 µl | EUR 362.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody |
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| abx413626-200l | Abbexa | 200 µl | EUR 525 |
CD45RA Antigen / PTPRC (CD45RA) Antibody |
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| abx414689-200l | Abbexa | 200 µl | EUR 350 |
CD45RA Antigen / PTPRC (CD45RA) Antibody |
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| abx415596-200l | Abbexa | 200 µl | EUR 462.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody |
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| abx415611-200l | Abbexa | 200 µl | EUR 175 |
Human Peripheral Blood CD8+ Activated T Killer Cells |
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| ABC-TC3987 | AcceGen | 1 vial | Ask for price |
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Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. |
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Human Normal Peripheral Blood CD8+ Cytotoxic T Cells |
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| PBCD8-F10M | 101Bio | 10 million | EUR 994.8 |
CD45RA |
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| 45RAA2-100T | ImmunoStep | 100 test | EUR 418.8 |
CD45RA |
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| 45RAB2-01MG | ImmunoStep | 100 test | EUR 340.8 |
CD45RA |
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| 45RACFB1-100T | ImmunoStep | 100 test | EUR 740.16 |
CD45RA |
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| 45RACFB2-100T | ImmunoStep | 100 test | EUR 465.6 |
CD45RA |
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| 45RAF1-100T | ImmunoStep | 100 test | EUR 387.6 |
CD45RA |
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| 45RAF2-100T | ImmunoStep | 100 test | EUR 356.4 |
CD45RA |
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| 45RAPE1-100T | ImmunoStep | 100 test | EUR 621.6 |
CD45RA |
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| 45RAPE2-100T | ImmunoStep | 100 test | EUR 418.8 |
CD45RA |
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| 45RAPP2-100T | ImmunoStep | 100 test | EUR 418.8 |
CD45RA |
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| 45RAPU1-01MG | ImmunoStep | 0,1 mg | EUR 262.8 |
CD45RA |
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| 45RAPU2-01MG | ImmunoStep | 0,1 mg | EUR 262.8 |
CD45RA |
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| V1027 | Antagene | 0.2mg | EUR 180 |
CD45RA |
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| MBS396644-01mg | MyBiosource | 0.1mg | EUR 280 |
CD45RA |
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| MBS396644-5x01mg | MyBiosource | 5x0.1mg | EUR 1115 |
CD45RA |
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| MBS370032-01mLConcentrate | MyBiosource | 0.1mL(Concentrate) | EUR 240 |
CD45RA |
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| MBS370032-05mLConcentrate | MyBiosource | 0.5mL(Concentrate) | EUR 375 |
CD45RA |
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| MBS370032-15mLRTU | MyBiosource | 15mL(RTU) | EUR 475 |
CD45RA |
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| MBS370032-3mLRTU | MyBiosource | 3mL(RTU) | EUR 240 |
CD45RA |
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| MBS370032-7mLRTU | MyBiosource | 7mL(RTU) | EUR 285 |
T-Pro Cell Counting Kit (CCK8) |
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| JK95-C008L | T-Pro Biotechnology | 5ml*20/BT | EUR 1000 |
T-Pro Cell Counting Kit (CCK8) |
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| JK95-C008M | T-Pro Biotechnology | 5ml*2/BT | EUR 120 |
T-Pro Cell Counting Kit (CCK8) |
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| JK95-C008S | T-Pro Biotechnology | 1ml*5/BT | EUR 80 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (PE) |
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| abx139831-100g | Abbexa | 100 µg | EUR 400 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (PE) |
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| abx228508-100g | Abbexa | 100 µg | EUR 62.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody (PE) |
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| abx413330-200l | Abbexa | 200 µl | EUR 637.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody (PE) |
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| abx414690-200l | Abbexa | 200 µl | EUR 512.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody (PE) |
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| abx415610-200l | Abbexa | 200 µl | EUR 487.5 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (RPE) |
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| abx413330-100tests | Abbexa | 100 tests | EUR 861.6 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (RPE) |
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| abx414690-100tests | Abbexa | 100 tests | EUR 710.4 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (RPE) |
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| abx415610-100tests | Abbexa | 100 tests | EUR 710.4 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (APC) |
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| abx139832-100g | Abbexa | 100 µg | EUR 400 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (APC) |
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| abx228509-100g | Abbexa | 100 µg | EUR 62.5 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx413328-01mg | Abbexa | 0.1 mg | EUR 777.6 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx414287-01mg | Abbexa | 0.1 mg | EUR 610.8 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx414687-01mg | Abbexa | 0.1 mg | EUR 610.8 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx415608-01mg | Abbexa | 0.1 mg | EUR 610.8 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx415609-25ug | Abbexa | 25 ug | EUR 326.4 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx139834-100g | Abbexa | 100 µg | EUR 350 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (FITC) |
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| abx228507-100g | Abbexa | 100 µg | EUR 62.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody (FITC) |
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| abx413328-200l | Abbexa | 200 µl | EUR 562.5 |
CD45RA Antigen / PTPRC (CD45RA) Antibody (FITC) |
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| abx414687-200l | Abbexa | 200 µl | EUR 425 |
CD45RA Antigen / PTPRC (CD45RA) Antibody (FITC) |
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| abx415609-200l | Abbexa | 200 µl | EUR 175 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (PerCP) |
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| abx139830-100g | Abbexa | 100 µg | EUR 400 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (PerCP) |
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| abx228510-100g | Abbexa | 100 µg | EUR 137.5 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (AF488) |
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| abx228515-100g | Abbexa | 100 µg | EUR 87.5 |
CD45RA Antigen (CD45RA/PTPRC) Antibody (AF647) |
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| abx228516-100g | Abbexa | 100 µg | EUR 125 |
DNA methylation standing of imprinted H19 and KvDMR1 genes in human placentas after conception utilizing assisted reproductive expertise
Background: Assisted reproductive applied sciences (ARTs), corresponding to in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), are thought to destabilize genomic imprints. Earlier research inspecting the affiliation between ART and aberrant DNA methylation have been inconclusive.
Technique: The DNA methylation standing of H19 and KvDMR1 was in contrast between newborns conceived by way of ART and people conceived naturally to guage the protection of ART. Placental tissues from 6 full-term, naturally conceived pregnancies (no gestational comorbidities) and 6 full-term ART pregnancies (no gestational complication) have been collected.
Genomic DNA (gDNA) and RNA have been extracted from each teams. Actual-time PCR was used to research the mRNA expression ranges of H19 and KvDMR1 within the placenta for each teams. A complete-genome DNA methylation microarray was used to look at three placentas from full-term, naturally conceived pregnancies and three placentas from full-term IVF pregnancies.
End result: The expression degree of H19 within the IVF group was considerably increased than that within the pure being pregnant group, whereas the expression degree of KvDMR1 was considerably decrease within the ART group than within the pure being pregnant group. Additionally, human ART manipulation resulted in placental gDNA methylation modifications.
Conclusion: Irregular methylation patterns have been detected in phenotypically regular phenotype conceived by ART, which can happen because of imprinting errors in sperm/oocyte cells or unwanted side effects of in vitro embryo tradition procedures. Additional investigation is important to decide whether or not imprinted gene expression and DNA methylation could be regulated by way of different mechanisms.
Key phrases: Assisted reproductive expertise (ART); placenta; methylation; H19; KvDMR1.
Human Umbilical Cord PrimaCell4: Normal Umbilical Vein Endothelial Cells |
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| 2-96109 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-01001 | Cyagen | 1*10^6/vial | EUR 1159 |
Human Umbilical Cord PrimaCell1: Normal Umbilical Artery Endothelial Cells |
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| 2-96106 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord PrimaCell5: Normal Umbilical Vein Smooth Muscle Cells |
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| 2-96110 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord PrimaCell2: Normal Umbilical Artery Smooth Muscle Cells |
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| 2-96107 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord-Derived Mesenchymal Stem Cells |
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| cAP-0052 | Angio Proteomie | 1Frozen Vial | EUR 594 |
Human Umbilical Cord-derived Mesenchymal Stem Cells |
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| CSC-00813L | Creative Bioarray | One Frozen vial | Ask for price |
Human Umbilical Cord PrimaCell4: Normal Umbilical Vein Endothelial Cells Growth Medium |
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| 9-46109 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord PrimaCell1: Normal Umbilical Artery Endothelial Cells Growth Medium |
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| 9-46106 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord Mesenchymal Stem Cells With GFP |
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| HUXUC-01101 | Cyagen | 1*10^6/vial | EUR 1599 |
Human Umbilical Cord PrimaCell5: Normal Umbilical Vein Smooth Muscle Cells Growth Medium |
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| 9-46110 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord PrimaCell2: Normal Umbilical Artery Smooth Muscle Cells Growth Medium |
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| 9-46107 | CHI Scientific | 5 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 4: Normal Umbilical Vein Endothelial Cells |
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| 9-80109 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Mesenchymal Stem Cells from Umbilical Cord Matrix |
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| CSC-C1223 | Creative Bioarray | One Frozen vial | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 1: Normal Umbilical Artery Endothelial Cells |
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| 9-80106 | CHI Scientific | 1 x 100 ml | Ask for price |
Rat Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells |
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| 2-82587 | CHI Scientific | 1 Kit | Ask for price |
Mouse Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells |
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| 2-82091 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 5: Normal Umbilical Vein Smooth Muscle Cells |
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| 9-80110 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Umbilical Cord Tissue Preparation Buffer 2: Normal Umbilical Artery Smooth Muscle Cells |
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| 9-80107 | CHI Scientific | 1 x 100 ml | Ask for price |
Human Primary Umbilical Cord-derived Mesenchymal Stem Cells |
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| T5483 | ABM | 1x10^6 cells / 1.0 ml | EUR 1275 |
Complete Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90011 | Cyagen | 500mL | EUR 319 |
RFP Expressing Human Umbilical Cord-Derived Mesenchymal Stem Cells |
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| cAP-0052RFP | Angio Proteomie | 1Frozen Vial | EUR 1188 |
RFP Expressing Human Umbilical Cord-Derived Mesenchymal Stem Cells |
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| RFP11 | Alphabioregen | 1ml frozen Vial | EUR 850 |
Serum Free Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90061 | Cyagen | 500mL | EUR 399 |
Rat Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Medium |
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| 9-25087 | CHI Scientific | 5 x 100 ml | Ask for price |
Serum, Human, Umbilical Cord |
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| MBS638841-10mL | MyBiosource | 10mL | EUR 560 |
Serum, Human, Umbilical Cord |
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| MBS638841-5x10mL | MyBiosource | 5x10mL | EUR 2375 |
Mouse Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Medium |
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| 9-32091 | CHI Scientific | 5 x 100 ml | Ask for price |
Rat Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
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| 9-80294 | CHI Scientific | 1 x 100 ml | Ask for price |
Umbilical Cord, Human Donor |
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| MBS170337-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Umbilical Cord Tissue Preparation Buffer: Normal Umbilical Vein Smooth Muscle Cells |
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| 9-80205 | CHI Scientific | 1 x 100 ml | Ask for price |
Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells-SV40T |
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| CSC-I2041Z | Creative Bioarray | One Frozen vial | Ask for price |
Immortalized Bovine Umbilical Cord Endothelial Cells (BUcEC) |
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| T0834 | ABM | 1x10^6 cells / 1.0 ml | Ask for price |
Conditionally Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells |
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| cAP-0062 | Angio Proteomie | 1Frozen Vial | EUR 5049 |
Conditionally Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells |
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| ALIMM007 | Alphabioregen | 1ml frozen Vial | EUR 0.1 |
Dog Primary Umbilical Cord-derived Mesenchymal Stem Cells |
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| T5490 | ABM | 1x10^6 cells / 1.0 ml | EUR 1145 |
Dog Primary Umbilical Cord-derived Mesenchymal Stem Cells |
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| T5491 | ABM | 1x10^6 cells / 1.0 ml | EUR 1145 |
Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells-SV40T+hTERT |
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| CSC-I2042Z | Creative Bioarray | One Frozen vial | Ask for price |
Human Umbilical Cord PrimaCell1: Normal Umbilical Artery Endothelial Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47106 | CHI Scientific | 1 Set | Ask for price |
Human Umbilical Cord PrimaCell4: Normal Umbilical Vein Endothelial Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47109 | CHI Scientific | 1 Set | Ask for price |
Single Donor Human Umbilical Cord |
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| IRHUSCD | Innovative research | each | EUR 957 |
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Description: Single Donor Human Umbilical Cord |
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Osteogenic Differentiation Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90021 | Cyagen | 200mL | EUR 250 |
Adipogenic Differentiation Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90031 | Cyagen | 200+100mL | EUR 359 |
Human Umbilical Cord PrimaCell5: Normal Umbilical Vein Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47110 | CHI Scientific | 1 Set | Ask for price |
Plasma, Human, Umbilical Cord, Frozen |
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| MBS634049-10mL | MyBiosource | 10mL | EUR 505 |
Plasma, Human, Umbilical Cord, Frozen |
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| MBS634049-1mL | MyBiosource | 1mL | EUR 250 |
Plasma, Human, Umbilical Cord, Frozen |
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| MBS634049-5x10mL | MyBiosource | 5x10mL | EUR 2060 |
Chondrogenic Differentiation Medium For Human Umbilical Cord Mesenchymal Stem Cells |
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| HUXUC-90041 | Cyagen | 100mL | EUR 409 |
Umbilical Cord Serum |
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| MBS592409-10mL | MyBiosource | 10mL | EUR 355 |
Umbilical Cord Serum |
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| MBS592409-50mL | MyBiosource | 50mL | EUR 1350 |
Human Umbilical Cord PrimaCell2: Normal Umbilical Artery Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-47107 | CHI Scientific | 1 Set | Ask for price |
Immortalized Human Umbilical Cord-Derived Mesenchymal Stem Cells-SV40 (Tet-on) |
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| CSC-I1909Z | Creative Bioarray | One Frozen vial | Ask for price |
Human Umbilical Cord Fetal Tissue Lysate |
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| IHUCDFSTL100UG | Innovative research | each | EUR 870 |
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Description: Human Umbilical Cord Fetal Tissue Lysate |
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Human Umbilical Cord Fetal Tissue Lysate |
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| MBS139153-01mg | MyBiosource | 0.1mg | EUR 1145 |
Human Umbilical Cord Fetal Tissue Lysate |
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| MBS139153-5x01mg | MyBiosource | 5x0.1mg | EUR 4960 |
Fetal Umbilical Cord Lysate |
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| XBL-10430 | ProSci | 0.1 mg | EUR 500.1 |
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Description: Fetal human umbilical cord tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human umbilical cord tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the umbilical cord tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The umbilical cord tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
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Rat Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-26087 | CHI Scientific | 1 Set | Ask for price |
Mouse Umbilical Cord PrimaCell: Normal Umbilical Vein Smooth Muscle Cells Growth Supplements with Serum (for 500 ml medium) |
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| 9-33091 | CHI Scientific | 1 Set | Ask for price |
Human Umbilical Cord OptiTDS1: Tissue Dissociation System |
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| 4-28106 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord OptiTDS2: Tissue Dissociation System |
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| 4-28107 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord OptiTDS4: Tissue Dissociation System |
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| 4-28109 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Cord OptiTDS5: Tissue Dissociation System |
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| 4-28110 | CHI Scientific | 1 Kit | Ask for price |
Human Umbilical Vein Endothelial Cells |
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| ABC-TC3848 | AcceGen | 1 vial | Ask for price |
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Description: HUVEC are isolated from the vein of the umbilical cord and are commonly used for physiological and pharmacological investigations, such as macromolecule transport, blood coagulation, angiogenesis, and fibrinolysis. Human umbilical vein endothelial cells have played a major role as a model system for the study of the regulation of endothelial cell function and the role of the endothelium in the response of the blood vessel wall to stretch, shear forces, and the development of atherosclerotic plaques.Each human umbilical cord vein is individually processed to isolate endothelial cells through collagenase digestion and culture. Frozen HUVEC products are cryopreserved at the end of the primary culture. HUVEC are guaranteed to reach 15 population doublings when cultured with Gentaur's recommended medium.Samples from each donor are tested via PCR to confirm non-reactivity. |
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Human ; Umbilical Vein Endothelial Cells |
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| 02-701 | Sceti | 100ng | EUR 481.2 |
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Description: The Human ; Umbilical Vein Endothelial Cells is available in Europe and for worldwide shipping via Gentaur. |
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Human Umbilical Vein Endothelial Cells |
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| HEC01 | Neuromics | 500,000+ Cells frozen | EUR 528 |
Human Umbilical Vein Endothelial Cells |
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| HUVEC-20001 | Cyagen | 1*10^6/vial | EUR 1100 |
Human Umbilical Vein Endothelial Cells |
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| CSC-C1578 | Creative Bioarray | One Frozen vial | Ask for price |
Human Umbilical Vein Endothelial Cells |
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| MBS556003-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Human Umbilical Artery Endothelial Cells |
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| ABC-TC3841 | AcceGen | 1 vial | Ask for price |
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Description: Gentaur endothelial cells from large vessels are available from different locations, e.g. umbilical vein, umbilical artery, aorta, coronary artery, pulmonary artery, and saphenous vein. In addition, Gentaur offers HUVEC isolated in standard Endothelial Cell Growth Medium and also in Endothelial Cell Growth Medium 2. The cells are supplied either from single donors or from pooled donors (from up to four different umbilical cords). Furthermore, HUVEC are available which are prescreened for VEGF (vascular endothelial cell growth factor) response. Shortly after isolation, Gentaur Human Endothelial Cells from large vessels are cryopreserved at passage 1 or passage 2 (see page 5) using Gentaur's proprietary, serum-free freezing medium, Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur. |
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Human Umbilical Vein Smooth Muscle Cells |
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| ABC-TC3857 | AcceGen | 1 vial | Ask for price |
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Description: Vascular smooth muscle cell is the cellular substate of most significant arterial disease. The increased growth potential of vascular smooth muscle cells represents one of the crucial anomalies responsible for the development of essential vascular diseases. New studies demonstrate that vascular smooth muscle cells express ICAM-1 and VCAM-1, which may contribute to the inflammatory reaction in the vascular wall and may actively be involved in the progression and stability of vascular disease. In vitro culture of human VSMC as a model of vascular research played a critical role and continues providing information in the pharmacology and the therapy of vascular diseases.HUVSMC from Gentaur Research Laboratories are isolated from human umbilical veins. HUVSMC are cryopreserved at the end of secondary culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HUVSMC are characterized by immunofluorescent method with antibodies to ?-smooth muscle actin and desmin. HUVSMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HUVSMC are guaranteed to further expand for 15 population doublings at the condition provided by Gentaur Research Laboratories. |
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Human Umbilical Artery Smooth Muscle Cells |
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| ABC-TC3843 | AcceGen | 1 vial | Ask for price |
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Description: Smooth muscle tissue is found in the tunica media layer of large and small blood vessels and in the walls of hollow organs like the bladder and the uterus. Smooth Muscle Cells (SMC) possess all the same types of filaments, but, depending on the tissue of origin, differ significantly in mechanical and physiological properties. Therefore, Gentaur offers a range of Human Smooth Muscle Cells produced at Gentaur's cell culture facility from normal human tissue of different origins. The cells are isolated from the aorta, the coronary artery, the pulmonary artery, the umbilical artery,the trachea, the bronchi, the bladder,the prostate, and the uterus. Shortly after isolation, all Gentaur Human Smooth Muscle Cells are cryopreserved at passage 2 (P2) using Gentaur's proprietary, serum-free freezing medium, Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur. |
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OCPB00610-100UG - Fetal Umbilical Cord Lysate |
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| OCPB00610-100UG | Aviva Systems Biology | 0.1mg | EUR 439 |
Human Umbilical Vein Endothelial Cells, Pooled |
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| ABC-TC3849 | AcceGen | 1 vial | Ask for price |
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Description: The cells are cryopreserved in the second passage to ensure the highest viability and plating efficiency. Primary pooled HUVECs are derived from 10 individual donors, minimizing the lot-to-lot variability associated with cells derived from single donors. |
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Human Umbilical Vein Endothelial Cells (HUVECs) |
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| cAP-0001 | Angio Proteomie | 1Frozen Vial | EUR 217.8 |
Human Umbilical Vein Endothelial Cells, Neonatal |
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| ABC-TC3853 | AcceGen | 1 vial | Ask for price |
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Description: Human Umbilical Vein Endothelial Cells (HUVEC) are isolated from normal human umbilical vein. They are cryopreserved at the end of primary culture and can be cultured and propagated at least 16 population doublings. |
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Human Umbilical Artery Endothelial Cells (HUAECs) |
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| cAP-0113 | Angio Proteomie | 1Frozen Vial | EUR 396 |
Human Primary Umbilical Vein Endothelial Cells |
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| T4098 | ABM | 5x10^5 cells / 1.0 ml | Ask for price |
Human Primary Umbilical Vein Endothelial Cells |
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| T5482 | ABM | 1x10^6 cells / 1.0 ml | EUR 765 |
Human Umbilical Artery Endothelial Cells, Neonatal |
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| ABC-TC3842 | AcceGen | 1 vial | Ask for price |
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Description: Human Umbilical Artery Endothelial Cells (HUAEC) are isolated from normal human umbilical arteries. They are cryopreserved at second passage and can be cultured and propagated at least 15 population doublings. |
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HighQC™ Human Mesenchymal Stem Cell (Umbilical Cord Matrix/ Cell Pellet In RNAlater) |
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| ABC-SC0038T | AcceGen | 1 vial | Ask for price |
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Description: Mesenchymal Stem Cells (MSC), also termed Mesenchymal Stromal Cells, are multipotent cells that can differentiate into a variety of cell types and have the capacity for self renewal. MSC have been shown to differentiate in vitro or in vivo into adipocytes, chondrocytes, osteoblasts, myocytes, neurons, hepatocytes, and pancreatic islet cells. Optimized Gentaur media are available to support both the growth of MSC and their differentiation into several different lineages. Recent experiments suggest that differentiation capabilities into diverse cell types vary between MSC of different origin.Gentaur hMSC are harvested from normal human adipose tissue, bone marrow, and umbilical cord matrix (Wharton's jelly) of individual donors.The cells are tested for their ability to differentiate in vitro into adipocytes, chondrocytes, and osteoblasts. Our hMSC show a verified marker expression profile that complies with ISCT* recommendations, providing well characterized cells. |
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Human Primary Umbilical Artery Endothelial Cells |
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| T4099 | ABM | 5x10^5 cells / 1.0 ml | Ask for price |
HighQC™ RFP-Human Umbilical Cord-Derived Mesenchymal Stem Cell |
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| ABC-FC0048 | AcceGen | 1 vial | Ask for price |
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Description: HUcMSCs are isolated from umbilical cord matrix (Wharton's Jelly) and demonstrated with spindle-shaped-, and fibroblast-like cells. RFP-HUcMSCs are puromycin resistant HUcMSCs after trandsfected with lentiviruses expressing RFP under the control of CMV protomer. Each lot of RFP-HUcMSCs is tested to ensure the cells can be passaged at least three times (i.e., approximately 9 to 10 population doublings) after thaw in complete growth media (Mesenchymal Stem Cell Growth Medium (MSCGM)), when cultured following the detailed protocol described below. |
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Innovative Grade US Origin Bovine Umbilical Cord |
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| IGBOCDF | Innovative research | each | EUR 210 |
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Description: Innovative Grade US Origin Bovine Umbilical Cord |
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Innovative Grade US Origin Bovine Umbilical Cord |
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| IGBOCDP | Innovative research | each | EUR 210 |
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Description: Innovative Grade US Origin Bovine Umbilical Cord |
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Innovative Grade US Origin Bovine Umbilical Cord |
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| IGBOCDS | Innovative research | each | EUR 133 |
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Description: Innovative Grade US Origin Bovine Umbilical Cord |
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Innovative Grade US Origin Bovine Umbilical Cord |
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| IGBOCDZ | Innovative research | each | EUR 133 |
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Description: Innovative Grade US Origin Bovine Umbilical Cord |
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Immortalized Human Umbilical Vein Endothelial Cells |
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| CSC-I9038L | Creative Bioarray | One Frozen vial | Ask for price |
Innovative Grade US Origin Porcine Umbilical Cord |
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| IGPCCDF | Innovative research | each | EUR 133 |
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Description: Innovative Grade US Origin Porcine Umbilical Cord |
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