aged-associated macrophage irritation to enhance bone regeneration

cd34stem

Maresin 1 resolves aged-associated macrophage irritation to enhance bone regeneration

 

Inflammaging is related to poor tissue regeneration noticed in superior age. Particularly, protracted irritation after acute damage has been related to decreased bone fracture therapeutic and elevated charges of nonunion in aged sufferers.
 Right here, we investigated the efficacy of utilizing Maresin 1 (MaR1), an omega-3 fatty acid-derived pro-resolving agent, to resolve irritation after tibial fracture damage and subsequently bettering aged bone therapeutic. Aged (24-month-old mice) underwent tibial fracture surgical procedure and had been both handled with car or MaR1 Three days after damage.
Fracture calluses had been harvested 7 days, 14 days, 21 days, and 28 days after damage to research inflammatory response, cartilage growth, bone deposition, and mechanical integrity, respectively. Therapeutic bones from MaR1-treated mice displayed decreased cartilage formation and elevated bone deposition which resulted in elevated structural stiffness and elevated pressure to fracture within the later levels of restore.
Within the early levels, MaR1 remedy decreased the variety of pro-inflammatory macrophages throughout the fracture callus and decreased the extent of inflammatory biomarkers in circulation. In tissue tradition fashions, MaR1 remedy of bone marrow-derived macrophages from aged mice protected cells kind a pro-inflammatory phenotype and induced an anti-inflammatory destiny.
Moreover, the secretome of MaR1-treated bone marrow-derived macrophages was recognized as osteoinductive, enhancing osteoblast differentiation of bone marrow stromal cells. Our findings right here establish decision of irritation, and MaR1 itself, to be a degree of intervention to enhance aged bone therapeutic.
Key phrases: bone; fracture therapeutic; inflammaging; macrophage; osteoblast.
cd34stem
cd34stem

anti-CD3 T-cell

501-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD3 T-cell

CD3, T-Cell; Polyclonal

A00030 6 ml
EUR 213

CD3, T-Cell; Polyclonal

A00030-0100 100 ml
EUR 2250

CD3, T-Cell; Polyclonal

A00030.0025 25 ml
EUR 621

CD3, T-Cell; Polyclonal

A20030 2 ml
EUR 130

Rat Pan B Cells antibody

10R-B124a 50 ug
EUR 759
Description: Mouse monoclonal Rat Pan B Cells antibody

anti-CD45 RA B-cells, T-cells, NK-cells

516-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD45 RA B-cells, T-cells, NK-cells

anti-CD45 RA B-cells, T-cells, NK-cells

516-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD45 RA B-cells, T-cells, NK-cells

anti-CD4 T helper cells

502-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD4 T helper cells

anti-CD4 T helper cells

502-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD4 T helper cells

anti-CD5 All T-cells

503-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD5 All T-cells

anti-CD5 All T-cells

503-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD5 All T-cells

anti-CD7 All T-cells

504-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD7 All T-cells

anti-CD7 All T-cells

504-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD7 All T-cells

Pan-Ras Activation Assay Kit, Trial Size

STA-400-T 5 assays
EUR 403
Description: Our Ras Activation Assays use visible agarose beads to selectively precipitate the active form of specific Ras protein of interest. The precipitated small GTPase is then detected by Western blot using a target-specific antibody included in the kit. Assays are available to detect specific isoforms H-Ras, K-Ras, and N-Ras, as well as a Pan-Ras assay that detects all three isoforms.

T-Pro Stacking Buffer

JB03-C002 500ml/BT
EUR 152

T-Pro MycoClean spray

JT90-R002 500ml/BT
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Rat Pan T cell antibody (biotin)

61R-T135aBT 200 ug
EUR 732
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Pan B-Cells (Ig Light Chain) Antibody

abx413491-01mg 0.1 mg
EUR 453

anti-CD8 T cytotoxic/supressor cells

505-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD8 T cytotoxic/supressor cells

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505-A-1000ug 1000 ug
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STJ16100972 1 mg
EUR 562

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EUR 648

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abx413492-100tests 100 tests
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T-Pro BCA Protein Assay kit

JB04-D001 500assay/KIT
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T-Pro Western Blot Stripping Reagent

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JT90-R001M 500ml/BT
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T-Pro EZ stain Gel solution

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T-Pro P-Fect Transfection Reagent

JT97-N005M 1.0ml/vial
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Testosterone (T) ELISA Kit

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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids.

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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids.

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T-Pro Fast Blocking Buffer (in PBS)

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Recombinant T-Cell Surface Glycoprotein CD3 Epsilon (CD3e)

4-RPD117Hu01
  • EUR 499.62
  • EUR 236.00
  • EUR 1598.56
  • EUR 599.52
  • EUR 1099.04
  • EUR 397.00
  • EUR 3846.40
  • 100 ug
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  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human T-Cell Surface Glycoprotein CD3 Epsilon expressed in: E.coli

Recombinant T-Cell Surface Glycoprotein CD3 Gamma (CD3g)

4-RPD118Hu01
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  • EUR 1612.00
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  • EUR 3880.00
  • 100 ug
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  • 1 mg
  • 200 ug
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Description: Recombinant Human T-Cell Surface Glycoprotein CD3 Gamma expressed in: E.coli

T-Cell Surface Glycoprotein CD3 Epsilon (CD3E) Antibody

20-abx111480
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody

20-abx104100
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  • 100 ug
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody

20-abx270014
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody

20-abx174729
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T-Pro Endotoxin Removal Plasmid Midi kit (25)

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T-Pro Laemmli (SDS sample) Reagent (reducing 4X)

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T-Pro Nonliposomal Transfection Reagent I (NTR I)

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General Testosterone (T) ELISA Kit

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General Testosterone (T) ELISA Kit

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T-Pro Gel/PCR DNA Purification Maxi Kit (10)

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T-Pro Laemmli (SDS sample) Reagent (non-reducing 4X)

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Human T-cell surface glycoprotein CD3 epsilon chain (CD3E)

1-CSB-RP104844h
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  • EUR 262.00
  • 100ug
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Description: Recombinant Human T-cell surface glycoprotein CD3 epsilon chain(CD3E) expressed in E.coli

Human T-cell surface glycoprotein CD3 epsilon chain (CD3E)

1-CSB-YP004931HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human T-cell surface glycoprotein CD3 epsilon chain(CD3E),partial expressed in Yeast

Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e)

1-CSB-YP004931MO
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain(Cd3e),partial expressed in Yeast

T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody

20-abx125312
  • EUR 495.00
  • EUR 704.00
  • EUR 356.00
  • 100 ul
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T-cell Surface Glycoprotein CD3 Zeta Chain (CD247) Antibody

20-abx121325
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3E) Antibody (HRP)

20-abx108798
  • EUR 411.00
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  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
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T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody

20-abx110253
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody

20-abx111481
  • EUR 732.00
  • EUR 398.00
  • 150 ul
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T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody

20-abx123523
  • EUR 411.00
  • EUR 592.00
  • 100 ul
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T-Cell Surface Glycoprotein CD3 Delta Chain (CD3D) Antibody

20-abx320335
  • EUR 300.00
  • EUR 244.00
  • 100 ul
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T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody

20-abx323664
  • EUR 314.00
  • EUR 244.00
  • 100 ug
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T-cell surface glycoprotein CD3 gamma chain (CD3G) Antibody

20-abx338816
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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  • 20 ug
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Robotic Excessive-Throughput Biomanufacturing and Practical Differentiation of Human Pluripotent Stem Cells

anti-CD4 T helper cells

502-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD4 T helper cells

anti-CD4 T helper cells

502-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD4 T helper cells

anti-CD5 All T-cells

503-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD5 All T-cells

anti-CD5 All T-cells

503-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD5 All T-cells

anti-CD7 All T-cells

504-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD7 All T-cells

anti-CD7 All T-cells

504-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD7 All T-cells

T-Pro Stacking Buffer

JB03-C002 500ml/BT
EUR 152

T-Pro MycoClean spray

JT90-R002 500ml/BT
EUR 144

MagIso CD8 T Cell Isolation Kit, Human

WHK-B002 10 tests
EUR 604

MagIso CD8 T Cell Isolation Kit, Mouse

WHK-B004 10 tests
EUR 604

T-Pro Plasmid Mini Kit (100)

RB94-YPD100 100preps/Kit
EUR 161

T-Pro Plasmid Mini Kit (250)

RB94-YPD250 250preps/Kit
EUR 222

T-Pro Plasmid Midi Kit (20)

RB94-YPI020 20preps/Kit
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T-Pro Plasmid Maxi Kit (10)

RB94-YPM010 10preps/Kit
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T-Pro EZ Gel Solution 8%

JB02-B008M 500ml/BT
EUR 222

T-Pro EZ Gel Solution 8%

JB02-B008S 100ml/BT
EUR 135

T-Pro EZ Gel Solution 10%

JB02-B010M 500ml/BT
EUR 222

T-Pro EZ Gel Solution 10%

JB02-B010S 100ml/BT
EUR 135

T-Pro EZ Gel Solution 12%

JB02-B012M 500ml/BT
EUR 222

T-Pro EZ Gel Solution 12%

JB02-B012S 100ml/BT
EUR 135

T-Pro EZ Gel Solution 15%

JB02-B015M 500ml/BT
EUR 222

T-Pro EZ Gel Solution 15%

JB02-B015S 100ml/BT
EUR 135

T-Pro Separating or Resolving Buffer

JB03-C001 500ml/BT
EUR 152

T-Pro BCA Protein Assay kit

JB04-D001 500assay/KIT
EUR 204

T-Pro Transfer Blotting buffer (10X)

JB08-H001 500ml/BT
EUR 135

T-Pro Western Blot Stripping Reagent

JB11-K002 500ml/BT
EUR 178

T-Pro Aqua EZ Clean (M)

JT90-R001M 500ml/BT
EUR 332

T-Pro Aqua EZ Clean (S)

JT90-R001S 100ml/BT
EUR 151

T-Pro EZ stain Gel solution

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T-Pro EZ stain Gel solution

JT90-R005S 100ml/BT
EUR 126

T-Pro P-Fect Transfection Reagent

JT97-N005M 1.0ml/vial
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MagIso CD8 Naïve T Cell Isolation Kit, Mouse

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Testosterone (T) ELISA Kit

DLR-T-Ge-48T 48T
EUR 469
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Testosterone (T) ELISA Kit

DLR-T-Ge-96T 96T
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids.

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JB04-D001A 500ml/BT
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JB04-D001B 12ml/BT
EUR 117

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EUR 161

T-Pro Fast Blocking Buffer (in PBS)

JK92-W001 500ml/BT
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T-Pro Fast Blocking Buffer (in TBS)

JK92-W002 500ml/BT
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CD8

8A1-100T 100 test
EUR 349

CD8

8A3-100T 100 test
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CD8

8AC750-100T 100 test
EUR 570

CD8

8B1-01MG 100 test
EUR 284

CD8

8CFB1-100T 100 test
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CD8

8DY1-100T 100 test
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CD8

8F1-100T 100 test
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CD8

8F3-100T 100 test
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CD8

8PE1-100T 100 test
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CD8

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CD8

8PPC5.5-100T 100 test
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CD8

8PU1-01MG 0,1 mg
EUR 219

T-Pro Endotoxin Removal Plasmid Midi kit (25)

RB94-EPI020 20preps/Kit
EUR 248

T-Pro Endotoxin Removal Plasmid Maxi kit (10)

RB94-EPM010 10preps/Kit
EUR 265

T-Pro Plant Genomic DNA Midi Kit (20)

RB94-PGM020 20preps/kit
EUR 222

T-Pro Plant Genomic DNA Mini Kit (100)

RB94-PGS100 100preps/kit
EUR 222

T-Pro Laemmli (SDS sample) Reagent (reducing 4X)

JB06-F002 10ml/BT
EUR 126

T-Pro Tris-Glycine-SDS running buffer (10X)

JB07-G001 500ml/BT
EUR 135

T-Pro Tris-Glycine-Native running buffer (10X)

JB07-G002 500ml/BT
EUR 135

T-Pro Semi Dry Transfer Blotting buffer (10X)

JB08-H002 500ml/BT
EUR 144

T-Pro Protein Free Blocking Buffer (in PBS)

JK92-W003 500ml/BT
EUR 187

T-Pro Protein Free Blocking Buffer (in TBS)

JK92-W004 500ml/BT
EUR 187

T-Pro Nonliposomal Transfection Reagent I (NTR I)

JT97-N001M 1.0ml/vial
EUR 187

T-Pro Nonliposomal Transfection Reagent II (NTR II)

JT97-N002M 1.0ml/vial
EUR 204

T-Pro Nonliposomal Transfection Reagent III (NTR III)

JT97-N006M 1.0ml/vial
EUR 222

Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A)

1-CSB-YP004966BO
  • EUR 679.00
  • EUR 335.00
  • EUR 2172.00
  • EUR 1051.00
  • EUR 1442.00
  • EUR 435.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain(CD8A),partial expressed in Yeast

Human T-cell surface glycoprotein CD8 alpha chain (CD8A)

1-CSB-YP004966HU
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human T-cell surface glycoprotein CD8 alpha chain(CD8A),partial expressed in Yeast

Human T-cell surface glycoprotein CD8 alpha chain (CD8A)

1-CSB-MP004966HU
  • EUR 293.00
  • EUR 963.00
  • EUR 409.00
  • EUR 717.00
  • 100ug
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human T-cell surface glycoprotein CD8 alpha chain(CD8A),partial expressed in Mammalian cell

Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A)

1-CSB-EP004966BO
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain(CD8A),partial expressed in E.coli

Human T-cell surface glycoprotein CD8 alpha chain (CD8A)

1-CSB-EP004966HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human T-cell surface glycoprotein CD8 alpha chain(CD8A),partial expressed in E.coli

T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody

20-abx125315
  • EUR 592.00
  • EUR 857.00
  • EUR 411.00
  • 100 ul
  • 200 ul
  • 50 ul

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody

20-abx321206
  • EUR 439.00
  • EUR 328.00
  • 100 ul
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T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody

20-abx002335
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody

abx140185-01mg 0.1 mg
EUR 314

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody

20-abx007884
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B1) Antibody

abx026526-400ul 400 ul
EUR 523

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B1) Antibody

abx026526-80l 80 µl
EUR 286

T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody

abx027833-400ul 400 ul
EUR 523

T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody

abx027833-80l 80 µl
EUR 286

T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody

abx027834-400ul 400 ul
EUR 523

T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody

abx027834-80l 80 µl
EUR 286

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody

abx028037-400ul 400 ul
EUR 523

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody

abx028037-80l 80 µl
EUR 286

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