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aged-associated macrophage irritation to enhance bone regeneration
Edwin- posted on
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Maresin 1 resolves aged-associated macrophage irritation to enhance bone regeneration
Inflammaging is related to poor tissue regeneration noticed in superior age. Particularly, protracted irritation after acute damage has been related to decreased bone fracture therapeutic and elevated charges of nonunion in aged sufferers.
Right here, we investigated the efficacy of utilizing Maresin 1 (MaR1), an omega-3 fatty acid-derived pro-resolving agent, to resolve irritation after tibial fracture damage and subsequently bettering aged bone therapeutic. Aged (24-month-old mice) underwent tibial fracture surgical procedure and had been both handled with car or MaR1 Three days after damage.
Fracture calluses had been harvested 7 days, 14 days, 21 days, and 28 days after damage to research inflammatory response, cartilage growth, bone deposition, and mechanical integrity, respectively. Therapeutic bones from MaR1-treated mice displayed decreased cartilage formation and elevated bone deposition which resulted in elevated structural stiffness and elevated pressure to fracture within the later levels of restore.
Within the early levels, MaR1 remedy decreased the variety of pro-inflammatory macrophages throughout the fracture callus and decreased the extent of inflammatory biomarkers in circulation. In tissue tradition fashions, MaR1 remedy of bone marrow-derived macrophages from aged mice protected cells kind a pro-inflammatory phenotype and induced an anti-inflammatory destiny.
Moreover, the secretome of MaR1-treated bone marrow-derived macrophages was recognized as osteoinductive, enhancing osteoblast differentiation of bone marrow stromal cells. Our findings right here establish decision of irritation, and MaR1 itself, to be a degree of intervention to enhance aged bone therapeutic.
Key phrases: bone; fracture therapeutic; inflammaging; macrophage; osteoblast.
CD3, T-Cell; Polyclonal |
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| A20030 | ScyTek Laboratories | 2 ml | EUR 156 |
CD3, T-Cell; Polyclonal |
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| A00030 | ScyTek Laboratories | 6 ml | EUR 255.6 |
CD3, T-Cell; Polyclonal |
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| A00030-0100 | ScyTek Laboratories | 100 ml | EUR 2700 |
CD3, T-Cell; Polyclonal |
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| A00030.0025 | ScyTek Laboratories | 25 ml | EUR 745.2 |
Rat Pan B Cells antibody |
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| 10R-B124a | Fitzgerald | 50 ug | EUR 910.8 |
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Description: Mouse monoclonal Rat Pan B Cells antibody |
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anti-CD45 RA B-cells, T-cells, NK-cells |
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| 516-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD45 RA B-cells, T-cells, NK-cells |
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anti-CD45 RA B-cells, T-cells, NK-cells |
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| 516-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD45 RA B-cells, T-cells, NK-cells |
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T-Pro Stacking Buffer |
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| JB03-C002 | T-Pro Biotechnology | 500ml/BT | EUR 182.4 |
T-Pro MycoClean spray |
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| JT90-R002 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
anti-CD4 T helper cells |
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| 502-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD4 T helper cells |
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anti-CD4 T helper cells |
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| 502-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD4 T helper cells |
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anti-CD5 All T-cells |
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| 503-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD5 All T-cells |
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anti-CD5 All T-cells |
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| 503-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD5 All T-cells |
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anti-CD7 All T-cells |
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| 504-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD7 All T-cells |
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anti-CD7 All T-cells |
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| 504-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD7 All T-cells |
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Anti-CD19 CAR-T Cells |
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| 78171-1 | BPS Bioscience | 1 vial | EUR 1595 |
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Description: The anti-CD19 CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ; SIN Vector, BPS Bioscience, #78601). These ready-to use CAR-T cells express an anti-CD19 CAR consisting the ScFv of CD19 (clone FMC63) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains. These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Anti-CD19 CAR-T Cells |
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| 78171-2 | BPS Bioscience | 5 vials | EUR 4250 |
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Description: The anti-CD19 CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ; SIN Vector). These ready-to use CAR-T cells express an anti-CD19 CAR consisting the ScFv of CD19 (clone FMC63) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains.These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Anti-BCMA CAR-T Cells |
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| 78660-1 | BPS Bioscience | 1 vial | EUR 1595 |
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Description: The anti-BCMA CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-BCMA CAR Lentivirus (BPS Bioscience #78655). These ready-to-use CAR-T cells express an anti-BCMA CAR consisting of the ScFv of BCMA (clone C11D5.3) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Anti-BCMA CAR-T Cells |
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| 78660-2 | BPS Bioscience | 5 vials | EUR 4250 |
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Description: The anti-BCMA CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-BCMA CAR Lentivirus (BPS Bioscience #78655). These ready-to-use CAR-T cells express an anti-BCMA CAR consisting of the ScFv of BCMA (clone C11D5.3) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Rat Pan T cell antibody (biotin) |
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| 61R-T135aBT | Fitzgerald | 200 ug | EUR 878.4 |
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Description: Mouse monoclonal Rat Pan T cell antibody (biotin) |
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Pan-Ras Activation Assay Kit, Trial Size |
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| STA-400-T | Cell Biolabs | 5 assays | EUR 483.6 |
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Description: Our Ras Activation Assays use visible agarose beads to selectively precipitate the active form of specific Ras protein of interest. The precipitated small GTPase is then detected by Western blot using a target-specific antibody included in the kit. Assays are available to detect specific isoforms H-Ras, K-Ras, and N-Ras, as well as a Pan-Ras assay that detects all three isoforms. |
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Pan B-Cells (Ig Light Chain) Antibody |
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| abx413491-01mg | Abbexa | 0.1 mg | EUR 543.6 |
T-Pro EZ Gel Solution 8% |
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| JB02-B008M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 8% |
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| JB02-B008S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 10% |
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| JB02-B010M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 10% |
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| JB02-B010S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 12% |
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| JB02-B012M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 12% |
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| JB02-B012S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 15% |
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| JB02-B015M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 15% |
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| JB02-B015S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro Separating or Resolving Buffer |
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| JB03-C001 | T-Pro Biotechnology | 500ml/BT | EUR 182.4 |
T-Pro BCA Protein Assay kit |
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| JB04-D001 | T-Pro Biotechnology | 500assay/KIT | EUR 244.8 |
T-Pro Transfer Blotting buffer (10X) |
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| JB08-H001 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Western Blot Stripping Reagent |
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| JB11-K002 | T-Pro Biotechnology | 500ml/BT | EUR 213.6 |
T-Pro Aqua EZ Clean (M) |
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| JT90-R001M | T-Pro Biotechnology | 500ml/BT | EUR 398.4 |
T-Pro Aqua EZ Clean (S) |
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| JT90-R001S | T-Pro Biotechnology | 100ml/BT | EUR 181.2 |
T-Pro EZ stain Gel solution |
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| JT90-R005M | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro EZ stain Gel solution |
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| JT90-R005S | T-Pro Biotechnology | 100ml/BT | EUR 151.2 |
T-Pro P-Fect Transfection Reagent |
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| JT97-N005M | T-Pro Biotechnology | 1.0ml/vial | EUR 266.4 |
T-Pro Plasmid Mini Kit (100) |
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| RB94-YPD100 | T-Pro Biotechnology | 100preps/Kit | EUR 193.2 |
T-Pro Plasmid Mini Kit (250) |
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| RB94-YPD250 | T-Pro Biotechnology | 250preps/Kit | EUR 266.4 |
T-Pro Plasmid Midi Kit (20) |
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| RB94-YPI020 | T-Pro Biotechnology | 20preps/Kit | EUR 255.6 |
T-Pro Plasmid Maxi Kit (10) |
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| RB94-YPM010 | T-Pro Biotechnology | 10preps/Kit | EUR 266.4 |
anti-CD8 T cytotoxic/supressor cells |
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| 505-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD8 T cytotoxic/supressor cells |
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anti-CD8 T cytotoxic/supressor cells |
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| 505-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD8 T cytotoxic/supressor cells |
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CD4+ T cells, Negatively Selected (Human) |
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| 79752 | BPS Bioscience | 10 million cells | EUR 395 |
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Description: Cryopreserved vial (10 x 10^6 cells) of CD4+ T cells that were negatively selected from freshly isolated primary human peripheral blood mononuclear cells (PBMCs). The PBMCs came from a healthy donor, and were isolated from whole blood or leukapheresis samples using a Ficoll gradient. Magnetic antibodies to monocytes, granulocytes, CD8+ T cells, gamma/delta T cells and other immune subsets present in PBMCs were then used to purify untouched CD4+ T cells via immunomagnetic separation. Before and after CD4+ T cell isolation, the cells were stained to evaluate purity and viability by flow cytometry. Cells were cryopreserved in CryoStor CS10 cryopreservation medium (Stemcell, #07930) at a controlled rate._x000D_Source Normal human PBMC from Leukapheresis Sample |
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CD8+ T cells, Negatively Selected (Human) |
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| 79753 | BPS Bioscience | 10 million cells | EUR 495 |
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Description: Cryopreserved vial (10 x 10^6 cells) of CD8+ T cells that were negatively selected from freshly isolated primary human peripheral blood mononuclear cells (PBMCs). The PBMCs came from a healthy donor, and were isolated from whole blood or leukapheresis samples using a Ficoll gradient. Magnetic antibodies to monocytes, granulocytes, CD4+ T cells, gamma/delta T cells and other immune subsets present in PBMCs were then used to purify untouched CD8+ T cells via immunomagnetic separation. Before and after CD8+ T cell isolation, the cells were stained to evaluate purity and viability by flow cytometry. Cells were cryopreserved in CryoStor CS10 cryopreservation medium (Stemcell, #07930) at a controlled rate._x000D_Source Normal human PBMC from Leukapheresis Sample |
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Anti-Guinea pig pan T-cell antibody |
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| STJ16100972 | St John's Laboratory | 1 mg | EUR 674.4 |
Pan B-Cells (Ig Light Chain) Antibody (FITC) |
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| abx413490-01mg | Abbexa | 0.1 mg | EUR 777.6 |
Pan B-Cells (Ig Light Chain) Antibody (RPE) |
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| abx413492-100tests | Abbexa | 100 tests | EUR 861.6 |
T-Pro BCA Protein Assay Reagent A |
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| JB04-D001A | T-Pro Biotechnology | 500ml/BT | EUR 204 |
T-Pro BCA Protein Assay Reagent B |
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| JB04-D001B | T-Pro Biotechnology | 12ml/BT | EUR 140.4 |
T-Pro Bradford Protein Assay kit(1X) |
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| JB04-D002 | T-Pro Biotechnology | 500ml/BT | EUR 193.2 |
T-Pro Fast Blocking Buffer (in PBS) |
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| JK92-W001 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Fast Blocking Buffer (in TBS) |
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| JK92-W002 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Genomic DNA Midi Kit (20) |
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| RB94-NGM020 | T-Pro Biotechnology | 20preps/kit | EUR 266.4 |
T-Pro Genomic DNA Mini Kit (100) |
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| RB94-NGS100 | T-Pro Biotechnology | 100preps/kit | EUR 255.6 |
Testosterone (T) ELISA Kit |
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| DLR-T-Ge-48T | DL Develop | 48T | EUR 562.8 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids. |
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Testosterone (T) ELISA Kit |
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| DLR-T-Ge-96T | DL Develop | 96T | EUR 729.6 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids. |
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T-Pro Laemmli (SDS sample) Reagent (reducing 4X) |
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| JB06-F002 | T-Pro Biotechnology | 10ml/BT | EUR 151.2 |
T-Pro Tris-Glycine-SDS running buffer (10X) |
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| JB07-G001 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Tris-Glycine-Native running buffer (10X) |
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| JB07-G002 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Semi Dry Transfer Blotting buffer (10X) |
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| JB08-H002 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
T-Pro Protein Free Blocking Buffer (in PBS) |
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| JK92-W003 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Protein Free Blocking Buffer (in TBS) |
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| JK92-W004 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Nonliposomal Transfection Reagent I (NTR I) |
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| JT97-N001M | T-Pro Biotechnology | 1.0ml/vial | EUR 224.4 |
T-Pro Nonliposomal Transfection Reagent II (NTR II) |
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| JT97-N002M | T-Pro Biotechnology | 1.0ml/vial | EUR 244.8 |
T-Pro Nonliposomal Transfection Reagent III (NTR III) |
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| JT97-N006M | T-Pro Biotechnology | 1.0ml/vial | EUR 266.4 |
T-Pro Endotoxin Removal Plasmid Midi kit (25) |
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| RB94-EPI020 | T-Pro Biotechnology | 20preps/Kit | EUR 297.6 |
T-Pro Endotoxin Removal Plasmid Maxi kit (10) |
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| RB94-EPM010 | T-Pro Biotechnology | 10preps/Kit | EUR 318 |
T-Pro Plant Genomic DNA Midi Kit (20) |
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| RB94-PGM020 | T-Pro Biotechnology | 20preps/kit | EUR 266.4 |
T-Pro Plant Genomic DNA Mini Kit (100) |
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| RB94-PGS100 | T-Pro Biotechnology | 100preps/kit | EUR 266.4 |
Locking T-Handle |
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| M-CP-111-065-T | MiTeGen | 1 UNIT | EUR 55 |
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Description: Locking T-Handle |
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody |
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| 20-abx104100 | Abbexa |
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3E) Antibody |
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| 20-abx111480 | Abbexa |
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody |
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| 20-abx270014 | Abbexa |
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T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody |
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| 20-abx174729 | Abbexa |
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Recombinant T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) |
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| 4-RPD117Hu01 | Cloud-Clone |
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Description: Recombinant Human T-Cell Surface Glycoprotein CD3 Epsilon expressed in: E.coli |
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Recombinant T-Cell Surface Glycoprotein CD3 Gamma (CD3g) |
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| 4-RPD118Hu01 | Cloud-Clone |
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Description: Recombinant Human T-Cell Surface Glycoprotein CD3 Gamma expressed in: E.coli |
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T-Pro Laemmli (SDS sample) Reagent (non-reducing 4X) |
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| JB06-F003 | T-Pro Biotechnology | 10ml/BT | EUR 151.2 |
T-Pro LumiFast Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K002M | T-Pro Biotechnology | 250ml*2/Kit | EUR 244.8 |
T-Pro LumiFast Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K002S | T-Pro Biotechnology | 100ml*2/Kit | EUR 182.4 |
T-Pro LumiLong Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K004M | T-Pro Biotechnology | 250ml*2/Kit | EUR 286.8 |
T-Pro LumiLong Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K004S | T-Pro Biotechnology | 100ml*2/Kit | EUR 204 |
T-Pro Gel/PCR DNA Purification Maxi Kit (10) |
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| RB94-NEL010 | T-Pro Biotechnology | 10preps/Kit | EUR 193.2 |
T-Pro Gel/PCR DNA Purification Mini Kit (100) |
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| RB94-NES100 | T-Pro Biotechnology | 100preps/Kit | EUR 193.2 |
T-Pro Gel/PCR DNA Purification Mini Kit (250) |
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| RB94-NES250 | T-Pro Biotechnology | 250preps/Kit | EUR 266.4 |
General Testosterone (T) ELISA Kit |
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| RD-T-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 560.4 |
General Testosterone (T) ELISA Kit |
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| RD-T-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 775.2 |
General Testosterone (T) ELISA Kit |
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| RDR-T-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 585.6 |
General Testosterone (T) ELISA Kit |
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| RDR-T-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 811.2 |
T-Pro Washing buffer in PBS and Tween-20 (10X) |
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| JB09-I003 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
T-Pro Washing buffer in TBS and Tween-20 (10X) |
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| JB09-I004 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
T-Pro Phosphate-Buffered Saline (PBS, 10X) for western blot washing |
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| JB09-I001 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Tris-Buffered Saline (TBS, 10X) for western blot washing |
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| JB09-I002 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody |
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| 20-abx149086 | Abbexa |
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T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody |
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| abx159386-100ul | Abbexa | 100 ul | EUR 427.2 |
Robotic Excessive-Throughput Biomanufacturing and Practical Differentiation of Human Pluripotent Stem Cells
Environment friendly translation of human induced pluripotent stem cells (hiPSCs) is dependent upon implementing scalable cell manufacturing methods that guarantee optimum self-renewal and purposeful differentiation.
Presently, guide tradition of hiPSCs is extremely variable and labor-intensive posing vital challenges for high-throughput purposes. Right here, we established a robotic platform and automatic all important steps of hiPSC tradition and differentiation below chemically outlined situations.
This streamlined method allowed speedy and standardized manufacturing of billions of hiPSCs that may be produced in parallel from as much as 90 totally different patient-and disease-specific cell traces. Furthermore, we established automated multi-lineage differentiation to generate major embryonic germ layers and extra mature phenotypes corresponding to neurons, cardiomyocytes, and hepatocytes.
To validate our method, we rigorously in contrast robotic and guide cell tradition and carried out molecular and purposeful cell characterizations (e.g. bulk tradition and single-cell transcriptomics, mass cytometry, metabolism, electrophysiology, Zika virus experiments) in order to benchmark industrial-scale cell tradition operations in direction of constructing an built-in platform for environment friendly cell manufacturing for illness modeling, drug screening, and cell remedy.
Combining stem cell-based fashions and continuous robotic cell tradition might change into a strong technique to extend scientific rigor and productiveness, that are significantly vital throughout public well being emergencies (e.g. opioid disaster, COVID-19 pandemic).
Talaromycosis in a Renal Transplant Recipient Getting back from South China
Talaromycosis is a fungal an infection endemic in Southeast Asia. We report a case of a renal transplant recipient who developed an infection after a visit to South China. She offered with constitutional signs and was discovered to have an FDG-avid lung mass. Histopathology demonstrated small yeast cells and the tradition grew Talaromyces marneffei.
The affected person was handled with 2 weeks of liposomal amphotericin B adopted by itraconazole. The dose of tacrolimus was considerably diminished due to the interplay with itraconazole. Mycophenolate mofetil was discontinued. After 12 months of remedy, the mass had fully resolved.
Talaromycosis has primarily been reported in sufferers with AIDS and is rare amongst stable organ transplant recipients. The immune response towards T. marneffei an infection is mediated predominantly by T-cells and macrophages. The analysis might not be suspected outdoors of endemic areas.
We suggest a therapeutic method in transplant sufferers by extrapolating the proof from the HIV literature and following practices utilized to different endemic mycoses.
Immortalized Mouse CD4+ CD8+ T Cells (MOHITO) |
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| T0131 | ABM | 1x106 cells / 1.0 ml | Ask for price |
anti-CD45 RA B-cells, T-cells, NK-cells |
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| 516-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD45 RA B-cells, T-cells, NK-cells |
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anti-CD45 RA B-cells, T-cells, NK-cells |
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| 516-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD45 RA B-cells, T-cells, NK-cells |
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T-Pro Stacking Buffer |
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| JB03-C002 | T-Pro Biotechnology | 500ml/BT | EUR 182.4 |
T-Pro MycoClean spray |
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| JT90-R002 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
anti-CD4 T helper cells |
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| 502-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD4 T helper cells |
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anti-CD4 T helper cells |
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| 502-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD4 T helper cells |
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anti-CD5 All T-cells |
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| 503-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD5 All T-cells |
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anti-CD5 All T-cells |
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| 503-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD5 All T-cells |
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anti-CD7 All T-cells |
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| 504-A-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: anti-CD7 All T-cells |
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anti-CD7 All T-cells |
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| 504-A-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: anti-CD7 All T-cells |
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Anti-CD19 CAR-T Cells |
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| 78171-1 | BPS Bioscience | 1 vial | EUR 1595 |
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Description: The anti-CD19 CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ; SIN Vector, BPS Bioscience, #78601). These ready-to use CAR-T cells express an anti-CD19 CAR consisting the ScFv of CD19 (clone FMC63) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains. These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Anti-CD19 CAR-T Cells |
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| 78171-2 | BPS Bioscience | 5 vials | EUR 4250 |
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Description: The anti-CD19 CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ; SIN Vector). These ready-to use CAR-T cells express an anti-CD19 CAR consisting the ScFv of CD19 (clone FMC63) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains.These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Anti-BCMA CAR-T Cells |
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| 78660-1 | BPS Bioscience | 1 vial | EUR 1595 |
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Description: The anti-BCMA CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-BCMA CAR Lentivirus (BPS Bioscience #78655). These ready-to-use CAR-T cells express an anti-BCMA CAR consisting of the ScFv of BCMA (clone C11D5.3) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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Anti-BCMA CAR-T Cells |
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| 78660-2 | BPS Bioscience | 5 vials | EUR 4250 |
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Description: The anti-BCMA CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-BCMA CAR Lentivirus (BPS Bioscience #78655). These ready-to-use CAR-T cells express an anti-BCMA CAR consisting of the ScFv of BCMA (clone C11D5.3) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. |
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MagIso CD8 T Cell Isolation Kit, Human |
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| WHK-B002 | Creative Diagnostics | 10 tests | EUR 724.8 |
MagIso CD8 T Cell Isolation Kit, Mouse |
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| WHK-B004 | Creative Diagnostics | 10 tests | EUR 724.8 |
T-Pro EZ Gel Solution 8% |
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| JB02-B008M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 8% |
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| JB02-B008S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 10% |
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| JB02-B010M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 10% |
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| JB02-B010S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 12% |
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| JB02-B012M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 12% |
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| JB02-B012S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro EZ Gel Solution 15% |
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| JB02-B015M | T-Pro Biotechnology | 500ml/BT | EUR 266.4 |
T-Pro EZ Gel Solution 15% |
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| JB02-B015S | T-Pro Biotechnology | 100ml/BT | EUR 162 |
T-Pro Separating or Resolving Buffer |
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| JB03-C001 | T-Pro Biotechnology | 500ml/BT | EUR 182.4 |
T-Pro BCA Protein Assay kit |
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| JB04-D001 | T-Pro Biotechnology | 500assay/KIT | EUR 244.8 |
T-Pro Transfer Blotting buffer (10X) |
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| JB08-H001 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Western Blot Stripping Reagent |
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| JB11-K002 | T-Pro Biotechnology | 500ml/BT | EUR 213.6 |
T-Pro Aqua EZ Clean (M) |
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| JT90-R001M | T-Pro Biotechnology | 500ml/BT | EUR 398.4 |
T-Pro Aqua EZ Clean (S) |
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| JT90-R001S | T-Pro Biotechnology | 100ml/BT | EUR 181.2 |
T-Pro EZ stain Gel solution |
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| JT90-R005M | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro EZ stain Gel solution |
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| JT90-R005S | T-Pro Biotechnology | 100ml/BT | EUR 151.2 |
T-Pro P-Fect Transfection Reagent |
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| JT97-N005M | T-Pro Biotechnology | 1.0ml/vial | EUR 266.4 |
T-Pro Plasmid Mini Kit (100) |
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| RB94-YPD100 | T-Pro Biotechnology | 100preps/Kit | EUR 193.2 |
T-Pro Plasmid Mini Kit (250) |
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| RB94-YPD250 | T-Pro Biotechnology | 250preps/Kit | EUR 266.4 |
T-Pro Plasmid Midi Kit (20) |
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| RB94-YPI020 | T-Pro Biotechnology | 20preps/Kit | EUR 255.6 |
T-Pro Plasmid Maxi Kit (10) |
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| RB94-YPM010 | T-Pro Biotechnology | 10preps/Kit | EUR 266.4 |
CD4+ T cells, Negatively Selected (Human) |
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| 79752 | BPS Bioscience | 10 million cells | EUR 395 |
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Description: Cryopreserved vial (10 x 10^6 cells) of CD4+ T cells that were negatively selected from freshly isolated primary human peripheral blood mononuclear cells (PBMCs). The PBMCs came from a healthy donor, and were isolated from whole blood or leukapheresis samples using a Ficoll gradient. Magnetic antibodies to monocytes, granulocytes, CD8+ T cells, gamma/delta T cells and other immune subsets present in PBMCs were then used to purify untouched CD4+ T cells via immunomagnetic separation. Before and after CD4+ T cell isolation, the cells were stained to evaluate purity and viability by flow cytometry. Cells were cryopreserved in CryoStor CS10 cryopreservation medium (Stemcell, #07930) at a controlled rate._x000D_Source Normal human PBMC from Leukapheresis Sample |
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T-Pro BCA Protein Assay Reagent A |
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| JB04-D001A | T-Pro Biotechnology | 500ml/BT | EUR 204 |
T-Pro BCA Protein Assay Reagent B |
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| JB04-D001B | T-Pro Biotechnology | 12ml/BT | EUR 140.4 |
T-Pro Bradford Protein Assay kit(1X) |
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| JB04-D002 | T-Pro Biotechnology | 500ml/BT | EUR 193.2 |
T-Pro Fast Blocking Buffer (in PBS) |
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| JK92-W001 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Fast Blocking Buffer (in TBS) |
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| JK92-W002 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Genomic DNA Midi Kit (20) |
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| RB94-NGM020 | T-Pro Biotechnology | 20preps/kit | EUR 266.4 |
T-Pro Genomic DNA Mini Kit (100) |
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| RB94-NGS100 | T-Pro Biotechnology | 100preps/kit | EUR 255.6 |
MagIso CD8 Naïve T Cell Isolation Kit, Mouse |
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| WHK-B018 | Creative Diagnostics | 20 tests, 200 tests | Ask for price |
MagIso CD8 Naïve T Cell Isolation Kit, Human |
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| WHK-B025 | Creative Diagnostics | 20 tests, 200 tests | Ask for price |
MagIso CD8 Memory T Cell Isolation Kit, Human |
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| WHK-B026 | Creative Diagnostics | 20 tests, 200 tests | Ask for price |
Testosterone (T) ELISA Kit |
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| DLR-T-Ge-48T | DL Develop | 48T | EUR 562.8 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids. |
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Testosterone (T) ELISA Kit |
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| DLR-T-Ge-96T | DL Develop | 96T | EUR 729.6 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Testosterone (T) in samples from serum, plasma, urine or other biological fluids. |
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T-Pro Laemmli (SDS sample) Reagent (reducing 4X) |
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| JB06-F002 | T-Pro Biotechnology | 10ml/BT | EUR 151.2 |
T-Pro Tris-Glycine-SDS running buffer (10X) |
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| JB07-G001 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Tris-Glycine-Native running buffer (10X) |
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| JB07-G002 | T-Pro Biotechnology | 500ml/BT | EUR 162 |
T-Pro Semi Dry Transfer Blotting buffer (10X) |
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| JB08-H002 | T-Pro Biotechnology | 500ml/BT | EUR 172.8 |
T-Pro Protein Free Blocking Buffer (in PBS) |
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| JK92-W003 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Protein Free Blocking Buffer (in TBS) |
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| JK92-W004 | T-Pro Biotechnology | 500ml/BT | EUR 224.4 |
T-Pro Nonliposomal Transfection Reagent I (NTR I) |
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| JT97-N001M | T-Pro Biotechnology | 1.0ml/vial | EUR 224.4 |
T-Pro Nonliposomal Transfection Reagent II (NTR II) |
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| JT97-N002M | T-Pro Biotechnology | 1.0ml/vial | EUR 244.8 |
T-Pro Nonliposomal Transfection Reagent III (NTR III) |
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| JT97-N006M | T-Pro Biotechnology | 1.0ml/vial | EUR 266.4 |
T-Pro Endotoxin Removal Plasmid Midi kit (25) |
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| RB94-EPI020 | T-Pro Biotechnology | 20preps/Kit | EUR 297.6 |
T-Pro Endotoxin Removal Plasmid Maxi kit (10) |
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| RB94-EPM010 | T-Pro Biotechnology | 10preps/Kit | EUR 318 |
T-Pro Plant Genomic DNA Midi Kit (20) |
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| RB94-PGM020 | T-Pro Biotechnology | 20preps/kit | EUR 266.4 |
T-Pro Plant Genomic DNA Mini Kit (100) |
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| RB94-PGS100 | T-Pro Biotechnology | 100preps/kit | EUR 266.4 |
Locking T-Handle |
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| M-CP-111-065-T | MiTeGen | 1 UNIT | EUR 55 |
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Description: Locking T-Handle |
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T-Pro Laemmli (SDS sample) Reagent (non-reducing 4X) |
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| JB06-F003 | T-Pro Biotechnology | 10ml/BT | EUR 151.2 |
T-Pro LumiFast Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K002M | T-Pro Biotechnology | 250ml*2/Kit | EUR 244.8 |
T-Pro LumiFast Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K002S | T-Pro Biotechnology | 100ml*2/Kit | EUR 182.4 |
T-Pro LumiLong Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K004M | T-Pro Biotechnology | 250ml*2/Kit | EUR 286.8 |
T-Pro LumiLong Plus Chemiluminescence Detection Kit (ECL Kit) |
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| JT96-K004S | T-Pro Biotechnology | 100ml*2/Kit | EUR 204 |
T-Pro Gel/PCR DNA Purification Maxi Kit (10) |
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| RB94-NEL010 | T-Pro Biotechnology | 10preps/Kit | EUR 193.2 |
T-Pro Gel/PCR DNA Purification Mini Kit (100) |
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| RB94-NES100 | T-Pro Biotechnology | 100preps/Kit | EUR 193.2 |
T-Pro Gel/PCR DNA Purification Mini Kit (250) |
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| RB94-NES250 | T-Pro Biotechnology | 250preps/Kit | EUR 266.4 |
General Testosterone (T) ELISA Kit |
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| RD-T-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 560.4 |
General Testosterone (T) ELISA Kit |
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| RD-T-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 775.2 |
General Testosterone (T) ELISA Kit |
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| RDR-T-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 585.6 |
General Testosterone (T) ELISA Kit |
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| RDR-T-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 811.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159413-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159414-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159415-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159416-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159417-100ul | Abbexa | 100 ul | EUR 526.8 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159418-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159419-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody |
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| abx159420-100ul | Abbexa | 100 ul | EUR 427.2 |
T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody |
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| abx140185-01mg | Abbexa | 0.1 mg | EUR 376.8 |
T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody |
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| 20-abx007884 | Abbexa |
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